Poly(N-isopropylacrylamide) based pH- and temperature-sensitive ampholytic hydrogels with tunable mechanical, swelling and drug release properties

Şimşek C., Erbil C.

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, cilt.71, sa.15, ss.1148-1163, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 71 Sayı: 15
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1080/00914037.2021.1960333
  • Dergi Adı: INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Chimica, Compendex, INSPEC
  • Sayfa Sayıları: ss.1148-1163
  • Anahtar Kelimeler: 2-acrylamido-2-methylpropane sulfonic acid, ampholytic poly(N-isopropylacrylamide) hydrogels, compression modulus, diclofenac sodium release, dynamic swelling, N-[3-(dimethylamino)propyl] methacrylamideItaconic acid, ACID) HYDROGELS, BEHAVIOR, POLYMERS, WATER, EQUILIBRIUM, DIFFUSION, SYSTEMS, SOLUTE
  • İstanbul Teknik Üniversitesi Adresli: Evet

Özet

pH-/temperature-sensitive ampholytic poly(N-isopropylacrylamide) (PNIPAAm) hydrogels containing N-[3-(dimethylamino)propyl]methacrylamide-itaconic acid (DMAPMAAm-IA) and DMAPMAAm-AMPS (2-acrylamido-2-methylpropane sulfonic acid) comonomer pairs have been designed and then synthesized. The results showed that (i) disk diameters and transparencies in the range of pH 2-12 increased only with increasing content of AMPS in the ampholytic NIPAAm/DMAPMAAm/AMPS hydrogels containing 10.0 mol % of DMAPMAAm + AMPS mixtures; (ii) maximum compressive strengths of NIPAAm/IA (62.5 +/- 10.0 kPa) was higher than NIPAAm/AMPS (26.9 +/- 1.1 kPa) hydrogels in DDW at 37 degrees C. (iii) In case of DFNa release, the decreasing values of n (approximate to 0.30-0.50) indicated that ampholytic PNIPAAm hydrogels served as diffusion barrier.