The extreme temperatures and uneven distribution of rainfall associated with climate change are expected to affect agricultural productivity and food security. A study was conducted to evaluate the impact of climate change on wheat in southeastern regions of Turkey. The CERES-wheat crop simulation model was calibrated and evaluated with data from eight surveyed farms. The four farms were used for calibration and four for evaluation. Climate change scenarios were developed for the middle (2036-2065) and late 21st century (2066-2095) under representative concentration pathways (RCPs 4.5 and 8.5) for study sites in Islahiye and Nurdagi. Model calibration results showed a good agreement between observed and simulated yield with only a 1 to 11% range of error. The model evaluation results showed good fit between observed and simulated values of all parameters with % error ranged from 0.51 to 13.3%. Future climate change projections showed that maximum temperature (Tmax) will increase between 1.6 degrees C (RCP4.5) and 2.3 degrees C (RCP8.5), while minimum temperature (Tmin) will increase between 1.0 degrees C (RCP4.5) and 1.5 degrees C (RCP8.5) for mid-century. At the end of the century, Tmax is projected to increase from 2 degrees C (RCP4.5) to 4 degrees C (RCP8.5) and Tmin from 1.3 degrees C (RCP4.5) to 3.1 degrees C (RCP8.5). Climate change impacts results showed that future rise in temperature will reduce wheat yield by 16.3% in mid-century and 16.8% at the end of the century at Islahiye and for Nurdagi, while 13.0% in mid and 14.4% end of the century. The use of climate and crop modeling technique provides useful information in evaluating the climate change impacts and may assist stakeholders to make decisions to overcome the negative impacts in the near and long term.