In this study, 68 reinforced concrete columns were tested under uniaxial compression after being jacketed externally with carbon fiber-reinforced polymer (CFRP) sheets. Forty specimens were cast using low strength concrete and inadequate internal transverse reinforcement, while 28 specimens were cast with medium strength concrete and adequate internal transverse reinforcement. Thickness of the CFRP jacket, cross-section shape, concrete strength, amount of internal transverse reinforcement, corner radius, existence of predamage, loading type (monotonic or cyclic), and the bonding pattern (orientation, spacing, anchorage details, additional corner supports) of CFRP sheets were the main test parameters of this extensive experimental work. Test results showed that external confinement of columns with CFRP sheets resulted in an increase in ultimate strength and ductility. While the strength enhancement was more pronounced for specimens with circular cross section, specimens with square and rectangular cross sections exhibited larger ultimate axial deformations without a substantial loss in strength. The efficiency of retrofitting was much more pronounced in the case of relatively lower strength concrete. The proposed model, together with two other available models, were used for predicting the strength and corresponding axial deformations of more than 300 specimens tested by other researchers, as well as more than 100 specimens tested by the writers during this study and before. It was shown that the predicted results by the proposed model were in reasonable agreement with this extensive database of experimental studies.