Machine learning based microfluidic sensing device for viscosity measurements


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Mustafa A., Haider D., Barua A., Tanyeri M., Erten A. C., Yalcin O.

Sensors and Diagnostics, cilt.2, sa.6, ss.1509-1520, 2023 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 2 Sayı: 6
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1039/d3sd00099k
  • Dergi Adı: Sensors and Diagnostics
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.1509-1520
  • İstanbul Teknik Üniversitesi Adresli: Evet

Özet

A microfluidic sensing device utilizing fluid-structure interactions and machine learning algorithms is demonstrated. The deflection of microsensors due to fluid flow within a microchannel is analysed using machine learning algorithms to calculate the viscosity of Newtonian and non-Newtonian fluids. Newtonian fluids (glycerol/water solutions) within a viscosity range of 5-100 cP were tested at flow rates of 15-105 mL h−1 (γ = 60.5-398.4 s−1) using a sample volume of 80-400 μL. The microsensor deflection data were used to train machine learning algorithms. Two different machine learning (ML) algorithms, support vector machine (SVM) and k-nearest neighbour (k-NN), were employed to determine the viscosity of unknown Newtonian fluids and whole blood samples. An average accuracy of 89.7% and 98.9% is achieved for viscosity measurement of unknown solutions using SVM and k-NN algorithms, respectively. The intelligent microfluidic viscometer presented here has the potential for automated, real-time viscosity measurements for rheological studies.