Natural alginate biopolymer montmorillonite clay composites for vitamin B2 delivery

KAYGUSUZ H., UYSAL M., Adımcılar V., Erim F. B.

JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS, vol.30, no.1, pp.48-56, 2015 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 1
  • Publication Date: 2015
  • Doi Number: 10.1177/0883911514557014
  • Journal Name: JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.48-56
  • Keywords: Riboflavin, alginate, biopolymer, release, montmorillonite, CONTROLLED-RELEASE, DYNAMIC RELEASE, DRUG-DELIVERY, IN-VITRO, RIBOFLAVIN, BEADS, SYSTEM
  • Istanbul Technical University Affiliated: Yes

Abstract

This work describes the in vitro release of a small drug, riboflavin, from novel calcium and barium crosslinked alginate-montmorillonite composite beads via oral route. Effect of crosslinking cation, concentration of montmorillonite and media on encapsulation efficiencies, and release profiles of riboflavin were studied. Beads were characterized using gravimetric swelling ability study, Fourier transform infrared spectroscopy, and scanning electron microscopy. Results indicate that addition of montmorillonite increases the encapsulation efficiencies and slows down the release rates significantly.