The Molecular Docking of Flavonoids Isolated from Daucus carota as a Dual Inhibitor of MDM2 and MDMX

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Atıf İçin Kopyala

Muhammad I., Rahman N., Nayab G. E. , Niaz S., Shah M., Afridi S. G. , ...Daha Fazla

RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY, cilt.15, sa.2, ss.154-164, 2020 (SCI İndekslerine Giren Dergi)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 15 Konu: 2
• Basım Tarihi: 2020
• Doi Numarası: 10.2174/1574892815666200226112506
• Dergi Adı: RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY
• Sayfa Sayıları: ss.154-164

Özet

Background: Cancer is characterized by overexpression of p53 associated proteins, which down-regulate P53 signaling pathway. In cancer therapy, p53 activity can be restored by inhibiting the interaction of MDMX (2N0W) and MDM2 (4JGR) proteins with P53 protein.