The Molecular Docking of Flavonoids Isolated from Daucus carota as a Dual Inhibitor of MDM2 and MDMX

Muhammad I., Rahman N., Nayab G. E., Niaz S., Shah M., Afridi S. G., ...Daha Fazla

RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY, cilt.15, sa.2, ss.154-164, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 2
  • Basım Tarihi: 2020
  • Doi Numarası: 10.2174/1574892815666200226112506
  • Dergi Adı: RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aerospace Database, Agricultural & Environmental Science Database, Biotechnology Research Abstracts, Chemical Abstracts Core, Communication Abstracts, EMBASE, MEDLINE, Metadex, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.154-164
  • İstanbul Teknik Üniversitesi Adresli: Evet

Özet

Background: Cancer is characterized by overexpression of p53 associated proteins, which down-regulate P53 signaling pathway. In cancer therapy, p53 activity can be restored by inhibiting the interaction of MDMX (2N0W) and MDM2 (4JGR) proteins with P53 protein.