The Molecular Docking of Flavonoids Isolated from Daucus carota as a Dual Inhibitor of MDM2 and MDMX

Muhammad I., Rahman N., Nayab G. E., Niaz S., Shah M., Afridi S. G., ...More

RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY, vol.15, no.2, pp.154-164, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 2
  • Publication Date: 2020
  • Doi Number: 10.2174/1574892815666200226112506
  • Journal Name: RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aerospace Database, Agricultural & Environmental Science Database, Biotechnology Research Abstracts, Chemical Abstracts Core, Communication Abstracts, EMBASE, MEDLINE, Metadex, Civil Engineering Abstracts
  • Page Numbers: pp.154-164
  • Istanbul Technical University Affiliated: Yes

Abstract

Background: Cancer is characterized by overexpression of p53 associated proteins, which down-regulate P53 signaling pathway. In cancer therapy, p53 activity can be restored by inhibiting the interaction of MDMX (2N0W) and MDM2 (4JGR) proteins with P53 protein.