The Molecular Docking of Flavonoids Isolated from Daucus carota as a Dual Inhibitor of MDM2 and MDMX


Muhammad I., Rahman N., Nayab G. E. , Niaz S., Shah M., Afridi S. G. , ...Daha Fazla

RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY, cilt.15, ss.154-164, 2020 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 15 Konu: 2
  • Basım Tarihi: 2020
  • Doi Numarası: 10.2174/1574892815666200226112506
  • Dergi Adı: RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY
  • Sayfa Sayıları: ss.154-164

Özet

Background: Cancer is characterized by overexpression of p53 associated proteins, which down-regulate P53 signaling pathway. In cancer therapy, p53 activity can be restored by inhibiting the interaction of MDMX (2N0W) and MDM2 (4JGR) proteins with P53 protein.