In the present study, the reaction conditions required for the oxidation of dimethyl phthalate (DMP), being selected as a model endocrine disrupting compound, with the H2O2/UV-C treatment process were optimized using central composite design and response surface methodology (CCD-RSM). Initial DMP (DMPo=20-100mg/L) concentration, initial H2O2 dosages (H2O2o=5-45mM), and treatment time (t(r)=2-18min) were selected as critical process parameters (independent variables) while DMP and total organic carbon (TOC) abatements were chosen as the responses (dependent variables). Analysis of variance revealed that the variables treatment time and initial DMP were the process-independent parameters most positively and negatively affecting the treatment performance, respectively. According to the established polynomial regression models, for the degradation of the DMP at an initial concentration of 60mg/L, the optimized treatment conditions were 25mM of H2O2o and treatment time of 10min. At these reaction conditions, complete DMP degradation and 28% TOC removal were obtained. By GC/MS analysis, phthalic acid and 4-hydroxy-1,2-benzoic dicarboxylic acid, dimethyl ester were identified as the aromatic oxidation intermediates.