Comfort properties of garments are influenced by fiber properties, fabric properties, and applied finishes. Denim garments are widely used apparels, and they are processed with different industrial finishing treatments. Finishing treatments and fabric weight have a great influence on the thermal comfort of denim fabrics. The aim of this paper was to evaluate the effects of finishing treatments (rigid, bleaching, resin, softener) on the thermophysiological comfort and moisture management properties of denim fabrics considering three weight categories (light, medium, heavy). The thermophysiological comfort (thermal resistance, thermal absorptivity, air permeability, water vapor permeability tests) and liquid moisture transport capabilities (transfer wicking and drying behavior of fabrics) were measured and analyzed statistically. As a result of the study, fabric weight and finishing had been found to be important parameters for the comfort properties of denim fabrics. As a conclusion, it could be stated in the light of the results that the fabric weight type (light, medium, heavy) had a significant impact on the fabric thermophysiological comfort properties.