Recent Advances on 3-Hydroxyflavone Derivatives: Structures and Properties


Butun B., Topcu G., Öztürk T.

MINI-REVIEWS IN MEDICINAL CHEMISTRY, cilt.18, sa.2, ss.98-103, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 18 Sayı: 2
  • Basım Tarihi: 2018
  • Doi Numarası: 10.2174/1389557517666170425102827
  • Dergi Adı: MINI-REVIEWS IN MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.98-103
  • İstanbul Teknik Üniversitesi Adresli: Evet

Özet

Flavonoids are naturally occurring phenolic compounds named as 2-phenyl-1-benzopyran4- one and classified into several subclasses according to their basic chemical structures such as flavones, flavonols, flavanones, flavanonols, and flavanols. Among them, flavonols (3-hydroxyflavone), containing a 3-hydroxyl group in association with its 4-keto group and double bond between 2-and 3-carbon atoms, have the best electron conjugated skeleton in flavonoid family, providing several resonance structures and chelating ability, through which various pharmacological activities such as antiviral, antitumour, anti-inflammatory, anticholinesterase, cytotoxicity and particularly high antioxidant activity are demonstrated. They prevent generation of free radicals and are used as food preservatives. Their strong electron conjugation provides them with fluorescent property, which make them used as imaging agents for therapeutic purpose.