In this study, a comparative design and analysis of a multi-story reinforced concrete building having reentrant corner irregularity by using Turkish, European and American standards were aimed, performing all analysis and design steps on the same structural model. For different countries' structural codes, period of the structure, base shear forces under seismic forces obtained using equivalent lateral load procedure, story drifts and second order effects were compared. The longitudinal reinforcement needed for the ground floor and reinforcement cost of the ground floor were calculated for each design code. For the building examined in this study, design made meeting the Eurocodes' requirements led to the most expensive solution, by providing a safer design. Although Turkish and American codes have a significant similarity in assumptions made and in procedure of design checks, Eurocodes and American codes gave closer results. Turkish Standard and Turkish Seismic Code 2007 gave the least conservative results and led to the most economical solution.