Dual laser activatable brominated hemicyanine as a highly efficient and photostable multimodal phototherapy agent

Gunduz H., Bilici K., Cetin S., Muti A., Sennaroglu A., Yagci Acar H., ...More

Journal of Photochemistry and Photobiology B: Biology, vol.217, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 217
  • Publication Date: 2021
  • Doi Number: 10.1016/j.jphotobiol.2021.112171
  • Journal Name: Journal of Photochemistry and Photobiology B: Biology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chemical Abstracts Core, Chimica, EMBASE, MEDLINE, Veterinary Science Database
  • Keywords: Cancer, Multimodal phototherapy, Small-molecule photosensitizers, Hemicyanine, Dual laser irradiation
  • Istanbul Technical University Affiliated: No


Dual phototherapy agents have attracted great interest in recent years as they offer enhanced cytotoxicity on cancer cells due to the synergistic effect of photodynamic and photothermal therapies (PDT/PTT). In this study, we demonstrate a brominated hemicyanine (HC-1), which is previously shown as mitochondria targeting PDT agent, can also serve as an effective photosensitizer for PTT for the first time under a single (640 nm or 808 nm) and dual laser (640 nm + 808 nm) irradiation. Generation of reactive oxygen species and photothermal conversion as a function of irradiation wavelength and power were studied. Both single wavelength irradiations caused significant phototoxicity in colon and cervical cancer cells after 5 min of irradiation. However, co-irradiation provided near-complete elimination of cancer cells due to synergistic action. This work introduces an easily accessible small molecule-based synergistic phototherapy agent, which holds a great promise towards the realization of local, rapid and highly efficient treatment modalities against cancer.