A SHORT NEW ROUTE TO THE PYRIDO[2,3,4-KL]ACRIDINE SUBUNIT COMMON TO PYRIDOACRIDINE ALKALOIDS OF MARINE ORIGIN


ALI N., CHATTOPADHYAY S., MCKILLOP A., PERRETGENTIL R., OZTURK T. , REBELO R.

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, no.19, pp.1453-1454, 1992 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 1992
  • Doi Number: 10.1039/c39920001453
  • Title of Journal : JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS
  • Page Numbers: pp.1453-1454

Abstract

A short new route to the pyrido[2,3,4-kl]acridine ring system has been developed from readily available quinoline precursors involving two key steps: (i) a palladium(O)-catalysed Suzuki cross-coupling reaction of 4-chloroquinolines with arylboronic acids, and (ii) an intramolecular nitrene insertion reaction of the nitrenes derived from 4-phenyl-5-azidoquinolines.