Polymeric Thioxanthones as Potential Anticancer and Radiotherapy Agents

Yilmaz G., Guler E., Barlas F. B., TİMUR S., Yağcı Y.

MACROMOLECULAR RAPID COMMUNICATIONS, cilt.37, sa.13, ss.1046-1051, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 37 Sayı: 13
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1002/marc.201600189
  • Dergi Adı: MACROMOLECULAR RAPID COMMUNICATIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1046-1051
  • İstanbul Teknik Üniversitesi Adresli: Evet

Özet

Thioxanthone (TX) and its derivatives, which are widely used as photoinitiators in UV curing technology, hold promising research interest in biological applications. In particular, the use of TXs as anticancer agent has recently been manifested as an outstanding additional property of this class of molecules. Incorporation of TX molecules into specially designed polymers widens their practical use in such applications. In this study, two water-soluble, biocompatible, and stable polymers, namely poly(vinyl alcohol) and poly(ethylene glycol), possessing TX moieties at the side chains and chain ends, respectively, are prepared and used as anticancer and radiotherapy agents. The findings confirm that both polymers are potential candidates for therapeutic agents as they possess useful features including water-solubility, radiosensitizer effect, and anticancer activity in a polymeric scaffold.