Biological Activity and Antioxidant Properties of Sodium Benzenesulfonate Based Imine Compounds


Yapar G. , Demir N., Yıldız M.

8. International Dug Chemistry Conference, Antalya, Turkey, 27 February - 01 March 2020, pp.242

  • Publication Type: Conference Paper / Summary Text
  • City: Antalya
  • Country: Turkey
  • Page Numbers: pp.242

Abstract

A Schiff base, is known as imine or azomethine, is a nitrogen analogue of an aldehyde or ketone in which the carbonyl group has been replaced by an imine or azomethine group. They are some of the most widely used important organic compounds. They have various industrial, analytical, biological, medical and pharmacological applications. They are used as catalysts, pigment dyes, sensors, complexing agents, antimicrobial, anticancer, antimalarial, analgesic and anticonvulsant1,2 . In this study, sodium benzenesulfonate based imines were synthesized. The structure of the compounds was determined by FTIR, UV-VIS, MS and NMR spectroscopy methods. The antimicrobial activities of the compounds have been investigated for their minimum inhibitory concentration (MIC) to bacteria and yeast cultures. The DNA binding of imines were investigated by UV-Visible spectra3 . The compounds interact with CT-DNA via electrostatic binding4 . The cleavage study was performed by gel-electrophoresis method using superwrapped (SC) plasmid pBR322 DNA in a medium TAE buffer. DNA cleavage study showed that the imines cleaved DNA oxidatively. In addition, antioxidant activities of Schiff base compouns were measured using the DPPH method. As the concentration of the compound increased, the antioxidant activity also increased.