PVP/flavonoid coprecipitation by supercritical antisolvent process


Özkan G., Franco P., Capanoglu E., De Marco I.

CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION, cilt.146, 2019 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 146
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.cep.2019.107689
  • Dergi Adı: CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Quercetin, Rutin, Polyphenols, Polyvinylpyrrolidone, Coprecipitated microparticles, SAS process, CARBON-DIOXIDE, SOLVENT MIXTURES, ALPHA-TOCOPHEROL, PHASE-EQUILIBRIA, QUERCETIN, RUTIN, MICROPARTICLES, PRECIPITATION, DELIVERY, PVP
  • İstanbul Teknik Üniversitesi Adresli: Evet

Özet

To date, various delivery systems have been developed to improve chemical stability and increase the bioavailability of polyphenolic compounds. In the present study, the micronization of two flavonoids, quercetin and rutin, and their coprecipitation with polyvinylpyrrolidone (PVP) were studied using the supercritical antisolvent process (SAS). SAS process parameters were optimized with the aim of obtaining composite microspheres with controlled mean size and particle size distribution. Spherical microparticles (with mean diameters in the range between 0.47 and 9.52 mu m for PVP/quercetin and in the range 0.84-8.17 mu m for PVP/rutin) were precipitated, depending on the operating conditions. In correspondence of the best operating conditions, the entrapment efficiency in PVP, for both flavonoids, was 99.8% and the dissolution rate from the coprecipitated powders was 10 and 3.19 times faster compared to the dissolution rates of unprocessed flavonoids for quercetin and rutin, respectively.