Aqueous colloidal nanoplatelets for imaging and improved ALA-based photodynamic therapy of prostate cancer cells

Onbasli K., Demirci G., Isik F., Durmusoglu E. G., Demir H. V., Acar H. Y.

Chemical Communications, 2023 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2023
  • Doi Number: 10.1039/d3cc02929h
  • Journal Name: Chemical Communications
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, EMBASE, MEDLINE, DIALNET
  • Istanbul Technical University Affiliated: No

Abstract

Fluorescent, CdSe/CdS core/crown heterostructured nanoplatelets (NPLs) were transferred to the water via a simple, single-step ligand exchange using 2-mercaptopropionic acid in a simple extraction process. These stable, aqueous NPLs were loaded with a modal drug, 5-aminolevulinic acid (ALA). ALA-loaded NPLs emerged as a new class of theranostic nanoparticles for image-guided enhanced photodynamic therapy of both androgen-dependent and -independent human prostate cancer cells.