Research Information System
THEORY IN BIOSCIENCES, vol.121, no.4, pp.387-394, 2003 (Journal Indexed in SCI)
We investigate a statistical model for multidimensional epistasis. The genotype is devided into subsequences, and within each subsequence mutations which occur in a prescribed order are beneficial. The bit-string model used to represent the genotype, may be cast in the form of a ferromagnetic Ising model with a staggered field. We describe the actual correlations between mutations at different sites, within an equilibrium population at a given tolerance, which we define to be the temperature of the statistical ensemble.