Nonwoven fabrics are very diverse in their structural properties. This paper discusses potential opportunities and challenges involved in jetting and depositing microdroplets on such materials. This study reports on the interaction of controlled droplets with the nonwoven substrates. Droplets used had velocities of about 1.8 m/s and diameters of about 90 m and were produced by using a drop-on-demand (DOD) inkjet printhead. Nonwovens used consisted of two groups of high and low solid volume fraction (SVF) substrates. The results indicate that in the case of low-SVF nonwovens, the local spacing and orientation of the fibres plays a significant role in determining the outcomes of the jetting process. Drops were seen to penetrate deep into a low-SVF nonwoven and deposit on a single fibre or bundle of fibres. Low-SVF nonwovens, therefore, can hold the fluid within their structuresa case of interest in printing electric circuits. The case of jetting on high-SVF nonwovens was found to be primarily dependent on the fibres' surface properties. The drops were found to stay above the surface in the case of hydrophobic fibres and below the surface in the case hydrophilic ones.