This paper studies the effect of the type and concentration of selected frothers, the gas flowrate, and the pore size of the porous frit on the bubble sizes (Sauter mean diameter, SMD) of bubbling flow produced in a micro-flotation cell, and the determination of bubble size distribution (BSD) in the presence of the frothers. The commercial frothers polypropylene glycols (PPG 200, 400, and 600), tri propylene glycol (BTPG), triethylene glycol (BTEG), dipropylene glycol (BDPG), and Methyl Isobutyl Carbinol (MIBC) were used in the present investigation. The frother concentration varied from 1 to 1000 ppm. The flow rate varied in the range of 25 to 100 cm(3)/min. The pore sizes of the frit were selected as 10-16 mu m, 16-40 mu m, and 40-100 mu m. Each frother exhibited its own unique ability in preventing coalescence of the bubbles in the order of BTEG < BDPG < PPG 200 < MIBC < BTPG < PPG 400 < PPG 600. The factorial experiments established that the type of the frother and its concentration have a major effect on the size of the bubbles. The bubbles decreased twice their size when the frother concentration was increased from 1 ppm to 1000 ppm. The pore size of the frit is a significant factor as well. The size of the bubbles can be reduced from about 10% to about 40% by decreasing the pores from 40-100 mu m to 10-16 mu m but the level of this decrease depends on the type of the frother. The increase of the flowrate from 25 cm(3)/min to 100 cm(3)/min produced bubbles smaller by 25% to 50% for the case of BTEG, BDPG, PPG 200, MIBC, BTPG, while a minimum of the bubble sizes was reached for the case of PPG 400 and PPG 600, beyond which the bubbles enlarged their size. The BSD in the presence of PPG 600 varied around 0.3 mm, whereas BTEG gave a wider BSD which indicated that the type of frother affected the bubble production. Our analysis shows that the first group of frothers adsorbs instantly on the bubbles, once they leave the porous frit, thus reaching equilibrium. PPG 400 and PPG 600 adsorb significantly slower on the bubbles, possibly not reaching equilibrium during their resident time.