Understanding the impacts of self-shuffling approach on structure and function of shuffled endoglucanase enzyme via MD simulations

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Yenenler A., Gerlevik U., SEZERMAN O. U.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.45, no.2, 2020 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 45 Issue: 2
• Publication Date: 2020
• Doi Number: 10.1515/tjb-2018-0180
• Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, TR DİZİN (ULAKBİM)
• Istanbul Technical University Affiliated: No

Abstract

Objective: We identify the impacts of structural differences on functionality of EG3_S2 endoglucanase enzyme with MD studies. The results of previous experimental studies have been explained in details with computational approach. The objective of this study is to explain the functional differences between shuffled enzyme (EG3_S2) and its native counterpart (EG3_nat) from Trichoderma reseei, via Molecular Dynamics approach.