Understanding the impacts of self-shuffling approach on structure and function of shuffled endoglucanase enzyme via MD simulations


Yenenler A., Gerlevik U., SEZERMAN O. U.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.45, sa.2, 2020 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 45 Konu: 2
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1515/tjb-2018-0180
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI

Özet

Objective: We identify the impacts of structural differences on functionality of EG3_S2 endoglucanase enzyme with MD studies. The results of previous experimental studies have been explained in details with computational approach. The objective of this study is to explain the functional differences between shuffled enzyme (EG3_S2) and its native counterpart (EG3_nat) from Trichoderma reseei, via Molecular Dynamics approach.