Bag-1 stimulates Bad phosphorylation through activation of Akt and Raf kinases to mediate cell survival in breast cancer


Kizilboga T., Baskale E. A. , Yildiz J., Akçay İ. M. , Zemheri E., Can N. D. , ...Daha Fazla

BMC CANCER, cilt.19, sa.1, 2019 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Konu: 1
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1186/s12885-019-6477-4
  • Dergi Adı: BMC CANCER

Özet

Background: Bag-1 (Bcl-2-associated athanogene) is a multifunctional anti-apoptotic protein frequently overexpressed in cancer. Bag-1 interacts with a variety of cellular targets including Hsp70/Hsc70 chaperones, Bcl-2, nuclear hormone receptors, Akt and Raf kinases. In this study, we investigated in detail the effects of Bag-1 on major cell survival pathways associated with breast cancer.