Effect of oil extract from microalgae (Schizochytrium sp.) on the viability and apoptosis of human osteosarcoma cells.

Sahin D.

Current pharmaceutical biotechnology, vol.22, pp.1099-1105, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22
  • Publication Date: 2021
  • Doi Number: 10.2174/1389201021666200928101029
  • Journal Name: Current pharmaceutical biotechnology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Page Numbers: pp.1099-1105
  • Keywords: Natural products, osteosarcoma, polyunsaturated fatty acids, Schizochytrium sp., apoptosis, omega-3, POLYUNSATURATED FATTY-ACIDS, CANCER-CELLS, DOCOSAHEXAENOIC ACID, OMEGA-3-FATTY-ACIDS, PROLIFERATION, TUMOR, CYTOTOXICITY, EPA
  • Istanbul Technical University Affiliated: Yes


Background: Osteosarcoma is a malignant tumor type that starts in bone and occurs most frequently in adolescents. Traditional techniques are insufficient, especially for metastatic ones. As alternative treatment techniques, natural products are worthy of examining due to being safe and innovative. Essential polyunsaturated fatty acids, mainly omega-3 and omega-6 fatty acids, have various positive effects on human health and growth. In addition, some PUFAs show anti-cancer activity by inducing apoptosis, specifically in cancer cells.