Medical compression stockings (MCS) are special products with high stretchability, which are frequently used for physical therapy of varicosities, lymphedema, deep vein thrombosis and, post thrombotic syndrome. They support blood flow and muscle systems by applying pressure to the leg and are in contact with the skin closely. During long flights, body's working system changes due to the low air pressure and dry air, and use of low pressure compression stockings reduces long flight related symptoms of discomfort, swelling, fatigue, aching and tightness. Generally, synthetic yarns are used in compression stockings, and low air and moisture permeability as well as short lifespan are their main problems. From this point of view, the aim of this study has been to minimize the complaints related to the lack of comfort of compression stockings by developing new products using cotton and biodegradable Umorfil nylon 6 (Umorfil (R) N6U) fiber which has collogen peptid bonds in its structure. The results showed that not only the developed stockings have relatively better comfort related properties than the ones from conventional nylon fiber but also they exhibit sufficient pressure performance for travel stockings.