In this paper we classified 4 skin lesions (Melanoma,Melanocytic Nevus, Basal Cell Carcinoma, Benign keratosis) from ISIC 2019 dataset which was published by International Skin Imaging Collabration in 2019. We used InceptionV3 convolutional neural network model for classification. We applied two preprocessing methods: High Dimensional Model Representation (HDMR) and Hilbert Transform. In conclusion we obtained 89% accuracy on classification of Basal Cell Carcinoma using Hilbert Transform. Moreover, we obtained 78% accuracy on classification of Melanoma using Contrast Enhancement High Dimensional Model Representation (HDMR).