DNA and BSA binding studies of novel tetracationic phthalocyanines

Öztürk R., Kalay Ş., Kalkan A., Türkan A., Abasiyanik M. F., Bayır Z., ...More

Journal of Porphyrins and Phthalocyanines, vol.12, no.8, pp.932-941, 2008 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 8
  • Publication Date: 2008
  • Doi Number: 10.1142/s1088424608000315
  • Journal Name: Journal of Porphyrins and Phthalocyanines
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.932-941
  • Keywords: Cationic phthalocyanines, DNA binding, Phthalocyanine-BSA interaction, Phthalocyanine-DNA interaction
  • Istanbul Technical University Affiliated: Yes

Abstract

The novel tetracationic metallophthalocyanines having diethylmethyl aminoethylsulfanyl groups on the periphery have been synthesized and characterized. The compounds tend to form aggregates in aqueous solutions. The aggregation of ZnPc4+ or CoPc4+, but not that of CuPc 4+, was hindered by the addition of surfactants (Triton X-100 and Tween 20). Using absorption and fluorescence spectroscopic techniques, DNA and BSA binding properties of tetracationic ZnPc in the presence of the surfactants were also investigated. Copyright © 2008 Society of Porphyrins & Phthalocyanines.