Technology Advancements in Blood Coagulation Measurements for Point-of-Care Diagnostic Testing

Aria M. M. , Erten A. C. , Yalcin O.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, vol.7, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 7
  • Publication Date: 2019
  • Doi Number: 10.3389/fbioe.2019.00395
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: blood coagulation, POC devices, electrochemical sensing, MEMS, fluorescent microscopy, microfluidics, nanomaterials, photoacoustic detection, SYNTHETIC URINARY BIOMARKERS, WHOLE-BLOOD, TISSUE FACTOR, IN-VIVO, ELECTRICAL-IMPEDANCE, PROTHROMBIN TIME, CLOT FORMATION, MICROFLUIDIC DEVICES, ULTRASONIC METHOD, SENSOR
  • Istanbul Technical University Affiliated: Yes


In recent years, blood coagulation monitoring has become crucial to diagnosing causes of hemorrhages, developing anticoagulant drugs, assessing bleeding risk in extensive surgery procedures and dialysis, and investigating the efficacy of hemostatic therapies. In this regard, advanced technologies such as microfluidics, fluorescent microscopy, electrochemical sensing, photoacoustic detection, and micro/nano electromechanical systems (MEMS/NEMS) have been employed to develop highly accurate, robust, and cost-effective point of care (POC) devices. These devices measure electrochemical, optical, and mechanical parameters of clotting blood. Which can be correlated to light transmission/scattering, electrical impedance, and viscoelastic properties. In this regard, this paper discusses the working principles of blood coagulation monitoring, physical and sensing parameters in different technologies. In addition, we discussed the recent progress in developing nanomaterials for blood coagulation detection and treatments which opens up new area of controlling and monitoring of coagulation at the same time in the future. Moreover, commercial products, future trends/challenges in blood coagulation monitoring including novel anticoagulant therapies, multiplexed sensing platforms, and the application of artificial intelligence in diagnosis and monitoring have been included.