In this paper, the fabrication of the photocured materials which contained silver nanoparticles (Ag-NPs) was studied on the properties of materials such as physical, mechanical and thermal properties, especially antibacterial activity. Therefore, silver nanoparticles were prepared and added into the polyurethane based matrix. Chemical and morphological structures of the photocured materials were characterized by FTIR and SEM analysis. SEM images proved the size of the silver nanoparticles and their dispersion into polymer matrix. Thermal, mechanical and optical properties of photocured materials results showed that the prepared polymer compositions containing Ag-NPs exhibited high modulus and better thermal property. Moreover, the antibacterial properties of the polyurethane based materials and polymer material containing AgNPs were determined and these AgNPs containing photocured materials pointed out good antibacterial activity against Escherichia coli and Staphylococcus aureus.