Cu2+-mediated complex formation between polyacrylic acid (PAA) and bovine serum albumin

Mustafaev M., Yucel F., Ozturk S., Cirakoglu B., Bermek E.

JOURNAL OF IMMUNOLOGICAL METHODS, vol.197, pp.31-37, 1996 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 197
  • Publication Date: 1996
  • Doi Number: 10.1016/0022-1759(96)00107-x
  • Journal Name: JOURNAL OF IMMUNOLOGICAL METHODS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.31-37
  • Istanbul Technical University Affiliated: No

Abstract

Cu2+-mediated complex formation between polyacrylic acid (PAA) and negatively charged bovine serum albumin (BSA) was studied in neutral water in the presence of Cu2+. Depending on the concentration of Cu2+, the reaction between PAA-Cu2+ complexes and BSA appeared to follow one of two possible paths. At low Cu2+ concentrations (n(Cu)/n(AA) < 0.15), a further increase in BSA concentration led to the breakdown of the complex as in mechanism I: