In this paper, we consider Universe filled with two-component fluid. We study two different models. In the first model we assume barotropic fluid with the linear equation of state (EoS) as the first component of total fluid. In the second model we assume van der Waals gas as the first component of total fluid. In both models, the second component assumed generalized ghost dark energy. We consider also interaction between components and discuss, numerically, cosmological quantities for two different parametrizations of EoS which varies with time. We consider this as a toy model of our Universe. We fix parameters of the model by using generalized second law of thermodynamics. Comparing our results with some observational data suggests interacting barotropic fluid with EoS parameter omega(t) = omega(0) cos(tH) + omega(1)t(H) over dot/H and generalized ghost dark energy as an appropriate model to describe our Universe.