Double click reaction strategies for polymer conjugation and post-functionalization of polymers

Durmaz H. , Sanyal A., Hızal G. , TUNCA Ü.

POLYMER CHEMISTRY, vol.3, no.4, pp.825-835, 2012 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Review
  • Volume: 3 Issue: 4
  • Publication Date: 2012
  • Doi Number: 10.1039/c1py00471a
  • Title of Journal : POLYMER CHEMISTRY
  • Page Numbers: pp.825-835


Double click reaction strategies, which are a combination of different type of click reactions, allow the preparation of polymers with various topologies and the post-functionalization of polymers, which cannot be easily achieved by using only one click reaction. The most studied click reaction combinations may be listed as the Cu(I) catalyzed azide-alkyne cycloaddition (CuAAC)-Diels-Alder, and the CuAAC-nitroxide radical coupling reactions for polymer-polymer conjugation and the CuAAC-Diels-Alder, or the CuAAC-thiol-ene reactions for post-modification of polymers.