Hydrophobic models of protein folding and the thermodynamics of chain-boundary interactions


Erzan A., Tuzel E.

BRAZILIAN JOURNAL OF PHYSICS, vol.33, no.3, pp.573-588, 2003 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 3
  • Publication Date: 2003
  • Doi Number: 10.1590/s0103-97332003000300018
  • Title of Journal : BRAZILIAN JOURNAL OF PHYSICS
  • Page Numbers: pp.573-588

Abstract

We review some results concerning the energetic and dynamical consequences of taking a generic hydrophobic model of a random polypeptide chain, where the effective hydrophobic interactions are represented by Hookcan springs. Then we present a set of calculations on a microscopic model of hydrophobic interactions, investigating the behaviour of a hydrophobic chain in the vicinity of a hydrophobic boundary. We conclude with some speculations as to the thermodynamics of pre-biotic functions proteins may have discharged very early on in the evolutionary past.