Hydrophobic models of protein folding and the thermodynamics of chain-boundary interactions

Erzan A., Tuzel E.

BRAZILIAN JOURNAL OF PHYSICS, cilt.33, sa.3, ss.573-588, 2003 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 3
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1590/s0103-97332003000300018
  • Dergi Adı: BRAZILIAN JOURNAL OF PHYSICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.573-588
  • İstanbul Teknik Üniversitesi Adresli: Hayır

Özet

We review some results concerning the energetic and dynamical consequences of taking a generic hydrophobic model of a random polypeptide chain, where the effective hydrophobic interactions are represented by Hookcan springs. Then we present a set of calculations on a microscopic model of hydrophobic interactions, investigating the behaviour of a hydrophobic chain in the vicinity of a hydrophobic boundary. We conclude with some speculations as to the thermodynamics of pre-biotic functions proteins may have discharged very early on in the evolutionary past.