Copy For Citation
Çini N., Çalışır F.
NANOMEDICINE, vol.17, no.25, pp.1961-1980, 2023 (SCI-Expanded)
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Publication Type:
Article / Review
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Volume:
17
Issue:
25
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Publication Date:
2023
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Doi Number:
10.2217/nnm-2022-0254
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Journal Name:
NANOMEDICINE
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Journal Indexes:
Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, BIOSIS, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
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Page Numbers:
pp.1961-1980
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Keywords:
drug delivery, drug loading, drug release, layer-by-layer deposition, LbL deposition, nanodrug delivery, nanomedicine, PEM, polyelectrolyte multilayers
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Istanbul Technical University Affiliated:
Yes
Abstract
New frontiers in the development of stimuli-responsive surfaces that offer switchable properties according to the end-use application have added a new dimension to the design of drug-delivery systems (DDS). In this respect, layer-by-layer (LbL) self-assembled technologies have attracted interest in nano-DDS (NDDS) design due to the advantage of encapsulating different drug types either individually or in multiple formulations as an easy-to-apply and cost-effective strategy. LbL-based microcapsules and core-shell structures in the form of polyelectrolyte multilayers (PEMs) have been proposed as versatile vehicles for NDDS over the last quarter. This review aims to provide a global view of LbL-PEMs used as templates in NDDS for the last 5 years with an emphasis on emerging drug loading and release strategies.