Layer-by-layer self-assembled emerging systems for nanosized drug delivery

Çini N., Çalışır F.

NANOMEDICINE, vol.17, no.25, pp.1961-1980, 2023 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 17 Issue: 25
  • Publication Date: 2023
  • Doi Number: 10.2217/nnm-2022-0254
  • Journal Name: NANOMEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, BIOSIS, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Page Numbers: pp.1961-1980
  • Keywords: drug delivery, drug loading, drug release, layer-by-layer deposition, LbL deposition, nanodrug delivery, nanomedicine, PEM, polyelectrolyte multilayers
  • Istanbul Technical University Affiliated: Yes


New frontiers in the development of stimuli-responsive surfaces that offer switchable properties according to the end-use application have added a new dimension to the design of drug-delivery systems (DDS). In this respect, layer-by-layer (LbL) self-assembled technologies have attracted interest in nano-DDS (NDDS) design due to the advantage of encapsulating different drug types either individually or in multiple formulations as an easy-to-apply and cost-effective strategy. LbL-based microcapsules and core-shell structures in the form of polyelectrolyte multilayers (PEMs) have been proposed as versatile vehicles for NDDS over the last quarter. This review aims to provide a global view of LbL-PEMs used as templates in NDDS for the last 5 years with an emphasis on emerging drug loading and release strategies.