A novel small-molecule antagonizes PRMT5-mediated KLF4 methylation for targeted therapy


Zhou Z., Feng Z., Hu D., Yang P., Gur M. , Bahar I., ...Daha Fazla

EBIOMEDICINE, cilt.44, ss.98-111, 2019 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 44
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.ebiom.2019.05.011
  • Dergi Adı: EBIOMEDICINE
  • Sayfa Sayıları: ss.98-111

Özet

Background: Triple negative breast cancers (TNBCs) have a poor prognosis and are not amenable to endocrine- or HER2-targeted therapies. The malignant and invasive feature of TNBCs is correlated with its high cancer stem cell population. Recent results from us and others have unveiled an oncogenic role for the PRMT5-KLF4 axis in regulating tumor progression by orchestrating the sternness in mammary tumor cell as well as genome stability. Methylation of KLF4 by PRMT5 leads to KLF4 stabilization, resulting in promoting mitogenesis.