Photophysicochemical behaviour and antimicrobial properties of monocarboxy Mg (II) and Al (III) phthalocyanine-magnetite conjugates

IDOWU M. A., XEGO S., Arslanoglu Y., MARK J., ANTUNES E., NYOKONG T.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, vol.193, pp.407-414, 2018 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 193
  • Publication Date: 2018
  • Doi Number: 10.1016/j.saa.2017.12.052
  • Journal Name: SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.407-414
  • Keywords: Asymmetric phthalocyanine, Magnetite, Nanopartides, Photodynamic antimicrobial chemotherapy (PACT), Singlet oxygen, PHOTODYNAMIC THERAPY, FLUORESCENT NANOCOMPOSITES, ALUMINUM PHTHALOCYANINES, SINGLET OXYGEN, NANOPARTICLES, WATER, SUBSTITUENTS, NANOEMULSION, DELIVERY, ZINC
  • Istanbul Technical University Affiliated: Yes

Abstract

Asymmetric Mg (II) or Al (III) phthalocyanine (containing a COOH group and 3-pyridylsulfanyl units) was conjugated via an amide bond to amino functionalized magnetic nanoparticle (AIMN) to form MgPc-AIMN or AlPc-AIMN conjugate, and characterized. The photophysicochemical behaviour of the phthalocyanine-AIMN conjugates was investigated and compared to the asymmetric Pcs and to the simple mixture of Pc with AIMNs without a chemical bond, (MPc-AIMN (mixed)). The directed covalent linkage of AIMNs to the asymmetrical metallopthalocyanines afforded improvements in the singlet oxygen (Phi(Delta)) and triplet state quantum yield (Phi(T)) as well as singlet oxygen lifetimes for the MPcs-AIMN-linked conjugates compared to MPc-AIMN (mixed) and MPcs alone. The asymmetric phthalocyanines and their conjugates showed effective antimicrobial activity against Escherichia coli bacteria under illumination. (C) 2017 Elsevier B.V. All rights reserved.