Photophysicochemical behaviour and antimicrobial properties of monocarboxy Mg (II) and Al (III) phthalocyanine-magnetite conjugates

IDOWU M. A., XEGO S., Arslanoglu Y., MARK J., ANTUNES E., NYOKONG T.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, cilt.193, ss.407-414, 2018 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 193
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.saa.2017.12.052
  • Dergi Adı: SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.407-414
  • Anahtar Kelimeler: Asymmetric phthalocyanine, Magnetite, Nanopartides, Photodynamic antimicrobial chemotherapy (PACT), Singlet oxygen, PHOTODYNAMIC THERAPY, FLUORESCENT NANOCOMPOSITES, ALUMINUM PHTHALOCYANINES, SINGLET OXYGEN, NANOPARTICLES, WATER, SUBSTITUENTS, NANOEMULSION, DELIVERY, ZINC
  • İstanbul Teknik Üniversitesi Adresli: Evet

Özet

Asymmetric Mg (II) or Al (III) phthalocyanine (containing a COOH group and 3-pyridylsulfanyl units) was conjugated via an amide bond to amino functionalized magnetic nanoparticle (AIMN) to form MgPc-AIMN or AlPc-AIMN conjugate, and characterized. The photophysicochemical behaviour of the phthalocyanine-AIMN conjugates was investigated and compared to the asymmetric Pcs and to the simple mixture of Pc with AIMNs without a chemical bond, (MPc-AIMN (mixed)). The directed covalent linkage of AIMNs to the asymmetrical metallopthalocyanines afforded improvements in the singlet oxygen (Phi(Delta)) and triplet state quantum yield (Phi(T)) as well as singlet oxygen lifetimes for the MPcs-AIMN-linked conjugates compared to MPc-AIMN (mixed) and MPcs alone. The asymmetric phthalocyanines and their conjugates showed effective antimicrobial activity against Escherichia coli bacteria under illumination. (C) 2017 Elsevier B.V. All rights reserved.