Rapid synthesis of polyester based single-chain polymeric nanoparticles via an intra-molecular aza-Michael addition reaction

Alkan B., Daglar O., TEMEL B., Durmaz H. , Temel G.

POLYMER CHEMISTRY, 2022 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Publication Date: 2022
  • Doi Number: 10.1039/d1py01631h
  • Title of Journal : POLYMER CHEMISTRY


An alternative strategy was developed to prepare intramolecularly crosslinked soft nanoparticles using the aza-Michael addition reaction of a linear polyester (PCA) containing in-chain reactive triple bonds. The linear precursor was achieved using the conventional polyesterification method in the presence of an acid catalyst. Single-chain polymeric nanoparticles were successfully synthesized by the aza-Michael addition route using a bifunctional amine compound and PCA in a short reaction period (15 min). The resulting polymeric nanoparticles exhibited lower hydrodynamic radii compared to their linear analogues (Rh < 5.55 nm). Crosslinked particles transformed into globular morphologies due to the collapse process as well. Additionally, the achieved nanoparticles were exploited for post-modifications via a thiol-Michael addition reaction.