Stability evaluation of interdigitated liposomes prepared with a combination of 1,2-distearoyl-sn-glycero-3-phosphocholine and 1,2-dilauroyl-sn-glycero-3-phosphocholine

Adrar N., BAHADORİ F., Ceylan F. D. , TOPÇU G., Bedjou F., Çapanoğlu Güven E.

JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, vol.96, no.9, pp.2537-2546, 2021 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 96 Issue: 9
  • Publication Date: 2021
  • Doi Number: 10.1002/jctb.6793
  • Title of Journal : JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
  • Page Numbers: pp.2537-2546
  • Keywords: liposomes, interdigitation, stability, DSPC, DLPC, ETHANOL INJECTION METHOD, PHASE-TRANSITIONS, PHOSPHOLIPID-BILAYERS, INDUCED AGGREGATION, PHOSPHATIDYLCHOLINE, VESICLES, ENCAPSULATION, DELIVERY, FUSION, SIZE

Abstract

BACKGROUND In order to obtain small and homogenous liposomes encapsulating gallic acid (GA) with interdigitated leaflets, a combination of phosphatidylcholine (PC) of medium length sn-1 and sn-2 acyl chains with PC of longer acyl chains at both sn1 and sn2 positions were employed. Four formulations respectively consisting of 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC); DSPC/1,2-dilauroyl-sn-glycero-3-phosphocholine (DSPC/DLPC) (1:1, mol mol(-1)); DSPC/DLPC (3:1, mol mol(-1)) and Lipoid S75, were prepared. For each formulation, the stability of liposomes during storage was investigated.