This paper presents results of in-plain shear tests carried out in ZAG laboratory in Ljubljana (Slovenia) on a RC frame with masonry infill made of clay blocks (KEBE OrthoBlock). The frame fixed at the bottom and loaded vertically at columns' tops was excited by horizontal cyclic loads at the top beam level. These loads forced various and gradually increasing drift levels (positive and negative) of the frame, with 3 repetitions at each level. Acquired forces and measured displacements allowed drawing hysteresis loops for determination of dissipation energy. Additionally, Digital Image Correlation (DIC) system was used for visualization of the behavior of the tested specimens.