New series of aromatic/five-membered heteroaromatic butanesulfonyl hydrazones as potent biological agents: Synthesis, physicochemical and electronic properties


Hamurcu F., Mamas S., Ozdemir U. O. , Gunduzalp A. B. , Senturk O. S.

JOURNAL OF MOLECULAR STRUCTURE, cilt.1118, ss.18-27, 2016 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 1118
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.molstruc.2016.03.092
  • Dergi Adı: JOURNAL OF MOLECULAR STRUCTURE
  • Sayfa Sayıları: ss.18-27

Özet

The aromatic/five-membered heteroaromatic butanesulfonylhydrazone derivatives; 5-bromosalicylalde hydebutanesulfonylhydrazone(1), 2-hydroxy-1-naphthaldehydebutane sulfonylhydrazone(2), indole-3-carboxaldehydebutanesulfonylhydrazone (3), 2-acetylfuran- carboxyaldehydebutanesulfonylhydrazone(4), 2-acetylthiophenecarboxyaldehydebutane- sulfonylhydrazone(5) and 2-acetyl-5-chlorothiophene carboxyaldehydebutanesulfonyl hydrazone (6) were synthesized by the reaction of butane sulfonic acid hydrazide with aldehydes/ketones and characterized by using elemental analysis, H-1 NMR, C-13 NMR and FT-IR technique. Their geometric parameters and electronic properties consist of global reactivity descriptors were also determined by theoretical methods. The electrochemical behavior of the butanesulfonylhydrazones were investigated by using cyclic voltammetry (CV), controlled potential electrolysis and chronoamperometry (CA) techniques. The number of electrons transferred (n), diffusion coefficient (D) and standard heterogeneous rate constants (k(s)) were determined by electrochemical methods. (C) 2016 Elsevier B.V. All rights reserved.