Dual Release Carriers for Cochlear Delivery

Rahmani S., ROSS A. M., Park T., Durmaz H., Dishman A. F., Prieskorn D. M., ...More

ADVANCED HEALTHCARE MATERIALS, vol.5, no.1, pp.94-101, 2016 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 5 Issue: 1
  • Publication Date: 2016
  • Doi Number: 10.1002/adhm.201500141
  • Journal Name: ADVANCED HEALTHCARE MATERIALS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.94-101
  • Istanbul Technical University Affiliated: No

Abstract

The fabrication of a carrier system capable of selectively encapsulating two therapeutics, piribedil and glial cell derived neurotrophic factor, in select compartments, and the programming of their independent release rates is investigated. The characterization of these particles, the release of each therapeutic, and the persistence of the particles within Guinea pig cochlea are assessed.