Direct reconstruction of kinetic parameter images from dynamic PET data


Kamasak M. E. , BOUMAN C., MORRIS E., SAUER K.

IEEE TRANSACTIONS ON MEDICAL IMAGING, cilt.24, ss.636-650, 2005 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 24 Konu: 5
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1109/tmi.2005.845317
  • Dergi Adı: IEEE TRANSACTIONS ON MEDICAL IMAGING
  • Sayfa Sayıları: ss.636-650

Özet

Our goal in this paper is the estimation of kinetic model parameters for each voxel corresponding to a dense three-dimensional (3-D) positron emission tomography (PET) image. Typically, the activity images are first reconstructed from PET sinogram frames at each measurement time, and then the kinetic parameters are estimated by fitting a model to the reconstructed time-activity response of each voxel. However, this "indirect" approach to kinetic parameter estimation tends to reduce signal-to-noise ratio (SNR) because of the requirement that the sinogram data be divided into individual time frames.