Direct reconstruction of kinetic parameter images from dynamic PET data


Kamasak M. E. , BOUMAN C., MORRIS E., SAUER K.

IEEE TRANSACTIONS ON MEDICAL IMAGING, vol.24, no.5, pp.636-650, 2005 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 5
  • Publication Date: 2005
  • Doi Number: 10.1109/tmi.2005.845317
  • Title of Journal : IEEE TRANSACTIONS ON MEDICAL IMAGING
  • Page Numbers: pp.636-650

Abstract

Our goal in this paper is the estimation of kinetic model parameters for each voxel corresponding to a dense three-dimensional (3-D) positron emission tomography (PET) image. Typically, the activity images are first reconstructed from PET sinogram frames at each measurement time, and then the kinetic parameters are estimated by fitting a model to the reconstructed time-activity response of each voxel. However, this "indirect" approach to kinetic parameter estimation tends to reduce signal-to-noise ratio (SNR) because of the requirement that the sinogram data be divided into individual time frames.