Conversion from clinically isolated syndrome to multiple sclerosis: A large multicentre study

Kuhle, J.; Disanto, G.; Dobson, R.; Adiutori, R.; Bianchi, L.; Topping, J.; Bestwick, J.; Meier, U-C; Marta, M.; Dalla Costa, G.; Runia, T.; Evdoshenko, E.; Lazareva, N.; Thouvenot, E.; Iaffaldano, P.; Direnzo, V.; Khademi, M.; Piehl, F.; Comabella, M.; Sombekke, M.; Killestein, J.; Hegen, H.; Rauch, S.; D'Alfonso, S.; Alvarez-Cermeno, J.; Kleinova, P.; Horakova, D.; Roesler, R.; Lauda, F.; Llufriu, S.; Avsar, T.; Uygunoglu, U.; Altintas, A.; Saip, S.; Menge, T.; Rajda, C.; Bergamaschi, R.; Moll, N.; Khalil, M.; Marignier, R.; Dujmovic, I.; Larsson, H.; Malmestrom, C.; Scarpini, E.; Fenoglio, C.; Wergeland, S.; Laroni, A.; Annibali, V.; Romano, S.; Martinez, A.; Carra, A.; Salvetti, M.; Uccelli, A.; Torkildsen, O.; Myhr, K.; Galimberti, D.; Rejdak, K.; Lycke, J.; Frederiksen, J.; Drulovic, J.; Confavreux, C.; Brassat, D.; Enzinger, C.; Fuchs, S.; Bosca, I.; Pelletier, J.; Picard, C.; Colombo, E.; Franciotta, D.; Derfuss, T.; Lindberg, R.; Yaldizli, Oe; Vecsei, L.; Kieseier, B.; Hartung, H.; Villoslada, P.; Siva, A.; Saiz, A.; Tumani, H.; Havrdova, E.; Villar, L.; Leone, M.; Barizzone, N.; Deisenhammer, F.; Teunissen, C.; Montalban, X.; Tintore, M.; Olsson, T.; Trojano, M.; Lehmann, S.; Castelnovo, G.; Lapin, S.; Hintzen, R.; Kappos, L.; Furlan, R.; Martinelli, V.; Comi, G.; Ramagopalan, S.; Giovannoni, G.

doi:10.1177/1352458514568827

Conversion from clinically isolated syndrome to multiple sclerosis: A large multicentre study

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Kuhle J., Disanto G., Dobson R., Adiutori R., Bianchi L., Topping J., ...More

MULTIPLE SCLEROSIS JOURNAL, vol.21, no.8, pp.1013-1024, 2015 (SCI-Expanded)

Publication Type: Article / Article
Volume: 21 Issue: 8
Publication Date: 2015
Doi Number: 10.1177/1352458514568827
Journal Name: MULTIPLE SCLEROSIS JOURNAL
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.1013-1024
Istanbul Technical University Affiliated: Yes

Abstract

Background and objective: We explored which clinical and biochemical variables predict conversion from clinically isolated syndrome (CIS) to clinically definite multiple sclerosis (CDMS) in a large international cohort.