A great amount of world energy demand is connected to the built environment. Electricity use in the commercial buildings, accounts for about one-third of the total energy consumption in Turkey and fully air-conditioned office buildings are important commercial electricity end-users since the mid-1990s. In the presented paper, the interactions between different conditions, control strategies and heating/cooling loads in office buildings in the four major climatic zones in Turkey - hot summer and cold winter, mild, hot summer and warm winter, hot and humid summer and warm winter - through building energy simulation program has been evaluated. The simulation results are compared with the values obtained from site measurements done in an office building located in Istanbul. The site-recorded data and simulation results are compared and analyzed. This verified model was used as a means to examine some energy conservation opportunities on annual cooling, heating and total building load at four major cities which were selected as a representative of the four climatic regions in Turkey. The effect of the parameters like the climatic conditions (location), insulation and thermal mass, aspect ratio, color of external surfaces, shading, window systems including window area and glazing system, ventilation rates and different outdoor air control strategies on annual building energy requirements is examined and the results are presented for each city. (C) 2007 Elsevier B.V. All rights reserved.