Acrylic Star Block Copolymers as Hydrophobic Drug Carriers

Tunca Ü., Tunca Ü., BAYRAKTAR O., Altintas O., Tunca Ü., Hızal G.

14th National Biomedical Engineering Meeting, İzmir, Turkey, 20 - 22 May 2009, pp.356-357 identifier identifier

  • Publication Type: Conference Paper / Full Text
  • Volume:
  • Doi Number: 10.1109/biyomut.2009.5130339
  • City: İzmir
  • Country: Turkey
  • Page Numbers: pp.356-357
  • Istanbul Technical University Affiliated: Yes

Abstract

Amphiphilic poly(methyl methacrylate)-b-poly(acrylic acid) (PMMA-b-PAA) copolymers with 4 and 6 arms were synthesized by Atomic Transfer Radical Polymerization (ATRP). The polymers were characterized by GPC, H-NMR and FTIR analysis. Polymer samples synthesized at various molecular weights between 18-80 kDa were investigated in terms of maximum loading capacity and critical micelle concentration by fluorescence spectroscopy. 4 arm PMMA-b-PAA (MW 30 kDa) was loaded with hydrophobic model drug indomethacin with an extremely high drug loading efficiency (22.5% drug content). Drug loaded polymer formed a stable and biodegradable complex in aqueous medium.