Multiphysics analysis and experimental validation of acoustic noise reduction in a high pole count, high power, switched reluctance machine (SRM), through skewing are explored in detail in this work. An iterative optimization strategy covering electromagnetic, structural, and thermal domains is proposed to investigate the effect of different skewing methods and angles on a 24-stator slot/16-rotor pole (24/16) SRM rated at 100 kW. The contributions of this work are twofold. First, electromagnetic impact, considering average torque, torque ripple, radial and tangential air gap forces, of symmetric and asymmetric skewing on stator and rotor is studied in this work. Second, the impact of skewing methods on acoustic noise and vibration performance is studied and presented in detail. The study reveals that skewing both the stator and rotor by the same amount has superior electromagnetic performance over other types of skewing. Multiphysics simulations conducted, predict a 10.5 dBA reduction in the acoustic noise, compared to a baseline design with no skew, for an optimized rotor-stator skewing angle of 13.75 degrees. Finally, 100 kW prototypes of the baseline and the optimized skewed SRM were constructed and subjected to wide speed range testing. Simulation and test results closely follow each other and validate the effectiveness of the proposed skew design in mitigating acoustic noise and vibration in high pole count SRMs.