In today's urbanizing world, home of 28 megacities, there is a growing need for tools to assess urban policies and support the design and implementation of effective development strategies. Unsustainable practices of urbanization bring major implications for land and environment, and cause a dramatic increase of urban vulnerability to natural hazards. In Istanbul megacity, disaster risk reduction represents a challenging issue for urban managers. In this paper, we show the relevance of the space-borne Differential SAR Interferometry (DInSAR) technique as a tool for supporting risk management, and thus contributing to achieve the urban sustainability. To this aim, we use a dataset of high resolution SAR images collected by the TerraSAR-X satellite that have been processed through the advanced (multi-temporal) Small BAseline Subset (SBAS)-DInSAR technique, thus producing spatially-dense deformation velocity maps and associated time-series. Results allow to depict an up-to-date picture of surface deformations occurring in Istanbul, and thus to identify urban areas subject to potential risk. The joint analysis of remotely sensed measurements and ancillary data (geological and urban development information) provides an opportunity for city planners and land professionals to discuss on the mutual relationship between urban development policies and natural/man-made hazards.