Comparative determination of the cardioselectivity of taxine and verapamil in the isolated aorta, atrium and jejunum preparations of rabbits

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Tekol Y., Gogusten B.

ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH, vol.49, no.8, pp.673-678, 1999 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 49 Issue: 8
• Publication Date: 1999
• Doi Number: 10.1055/s-0031-1300481
• Journal Name: ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.673-678
• Istanbul Technical University Affiliated: No

Abstract

The calcium channel antagonistic effect of taxine: (CAS 12607-93-1) (active principle of leaves of English yew; Taxus baccata L.) was investigated in isolated aorta of rabbit, and its organ selectivity was determined and compared with that of verapamil (CAS 52-53-9) in isolated aorta. atrium and jejunum preparations of rabbits.