Destructive deviant workplace behaviors are getting more and more important in today's business world. Although numerous researchers in the literature have tried to determine and clarify antecedents and consequences of deviant behaviors, studies on both alienation and deviance are limited. In this respect after a comprehensive literature review on the concept of workplace deviance, this paper provides a theoretical framework on some rarely studied predictors (i.e. person-organization fit, participative decision making, careerism) of it, where work alienation plays a mediator role. Managerial and further research implications are provided.