Research Information System
in: Regulatory T Cells , Xuehui He, Editor, IntechOpen, London, pp.1-25, 2022
The advent of new technologies in gene expression, immunology, molecular
biology, and computational modeling studies has expedited the discovery
process and provided us with a holistic view of host immune responses
that are highly regulated. The regulatory mechanisms of the immune
system lie not only in weakening the attacker directly but also in
fortifying the defender for the development of an efficient adaptive
immune response. This chapter reviews a comprehensive set of
experimental and bioinformatic studies designed to deepen the current
knowledge on the regulatory T cells (Tregs) in the context of Pattern
Recognition Receptors (PRRs). Initially, we examined both membrane-bound
Toll-like Receptors (TLRs) and C Type Lectin Receptors (CLRs); and
cytosolic NOD-like Receptors (NLRs) and RIG-I like Receptors (RLRs) in
Tregs. Then, we revisited the disease conditions associated with
regulatory T cells by emphasizing the essential roles of PRRs. Expanding
our knowledge and strategies on the regulatory mechanisms are likely to
provide our best chances for long-term disease control and maintenance
of homeostasis.