Ovarian antiproliferative activity directed isolation of triterpenoids from fruits of Eucalyptus camaldulensis Dehnh


TOPCU G., Yapar G., TURKMEN Z., GOREN A. C., OKSUZ S., SCHILLING J. K., ...Daha Fazla

PHYTOCHEMISTRY LETTERS, cilt.4, sa.4, ss.421-425, 2011 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 4 Sayı: 4
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.phytol.2011.05.002
  • Dergi Adı: PHYTOCHEMISTRY LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.421-425
  • İstanbul Teknik Üniversitesi Adresli: Evet

Özet

Bioassay-guided fractionation of a methanol extract of the fruits of Eucalyptus camaldulensis Dehnh. with moderate antiproliferative activity afforded the new triterpene, 3 beta-acetoxy-urs-11,13(18)-dien-28-oic acid (1) along with the known triterpenoids 3 beta-hydroxy-urs-11-en-28,13 beta-olide (2), 3 beta-acetoxy-urs-11-en-28,13 beta-olide (3), 3-acetylbetulinic acid (4), oleanolic acid (5), ursolic acid (6), beta-amyrin acetate (7), beta-sitosterol (8) and sitosterol 3-O-beta-D-glucopyranoside (9). Their structures were established on the basis of analysis of their (1)H and (13)C NMR, APT, gHSQC, gHMBC, UV, IR and mass spectral data. The tested triterpenoids (1-7) exhibited weak-moderate antiproliferative activity against the A2780 human ovarian cancer cell line. (C) 2011 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.