Determination of Serotonin-Norepinephrine Reuptake Inhibitor Antidepressants in Pharmaceuticals and Biological Material


Saka C., Sahin Ö.

CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY, vol.43, no.1, pp.2-34, 2013 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Review
  • Volume: 43 Issue: 1
  • Publication Date: 2013
  • Doi Number: 10.1080/10408347.2011.645377
  • Journal Name: CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2-34
  • Keywords: antidepressant, serotonin-norepinephrine reuptake inhibitors, analytical methods, pharmaceutical and biological samples, PERFORMANCE LIQUID-CHROMATOGRAPHY, TANDEM MASS-SPECTROMETRY, SOLID-PHASE EXTRACTION, SIMULTANEOUS STEREOSELECTIVE ANALYSIS, O-DESMETHYLVENLAFAXINE ENANTIOMERS, NEW-GENERATION ANTIDEPRESSANTS, SILICA STATIONARY-PHASE, N-DESMETHYL-METABOLITES, INDICATING HPTLC METHOD, HPLC METHOD DEVELOPMENT
  • Istanbul Technical University Affiliated: No

Abstract

Serotonin-norepinephrine reuptake inhibitors (SNRIs) are a newer form of antidepressant drugs. SNRIs include desvenlafaxine, duloxetine, milnacipran, venlafaxine, and sibutramine. The present study covers the analytical research on SNRIs and their main metabolites, focusing on bioanalytical and pharmaceutical applications. These analytical methods are generally chromatographic, electroanalytical, spectrometric, and electrophoretic methods.