Determination of Serotonin-Norepinephrine Reuptake Inhibitor Antidepressants in Pharmaceuticals and Biological Material


Saka C., Sahin Ö.

CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY, vol.43, no.1, pp.2-34, 2013 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Review
  • Volume: 43 Issue: 1
  • Publication Date: 2013
  • Doi Number: 10.1080/10408347.2011.645377
  • Title of Journal : CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
  • Page Numbers: pp.2-34
  • Keywords: antidepressant, serotonin-norepinephrine reuptake inhibitors, analytical methods, pharmaceutical and biological samples, PERFORMANCE LIQUID-CHROMATOGRAPHY, TANDEM MASS-SPECTROMETRY, SOLID-PHASE EXTRACTION, SIMULTANEOUS STEREOSELECTIVE ANALYSIS, O-DESMETHYLVENLAFAXINE ENANTIOMERS, NEW-GENERATION ANTIDEPRESSANTS, SILICA STATIONARY-PHASE, N-DESMETHYL-METABOLITES, INDICATING HPTLC METHOD, HPLC METHOD DEVELOPMENT

Abstract

Serotonin-norepinephrine reuptake inhibitors (SNRIs) are a newer form of antidepressant drugs. SNRIs include desvenlafaxine, duloxetine, milnacipran, venlafaxine, and sibutramine. The present study covers the analytical research on SNRIs and their main metabolites, focusing on bioanalytical and pharmaceutical applications. These analytical methods are generally chromatographic, electroanalytical, spectrometric, and electrophoretic methods.